Cybion – Transverse Tibia Transport System
TTT System – Transverse Tibia Transport System
The TTT system is designed to improve the treatment of diabetic foot ulcer and peripheral vascular conditions.
With this new treatment you could avoid lower limb amputations in Patients suffering from DFU.
Inspired by Ilizarov’s tension-stress principle, the transversal transport of the bone fragment generates the following effects:
- Reconstruction of the microvascular network (Neo-Vasculature)1
- Gradual increase in blood supply to the whole limb
- Improved circulation in the distal leg and foot
After more than 3 years and more than 1,200 documented cases in clinical research, the TTT system has proven to be an effective treatment to resolve a wide range of ischemic diseases of the lower limbs, especially offering a simple treatment for the management of patients with DFUs.
1-Li, G. (2022). Tibial cortex transverse transport accelerates wound healing via enhanced angiogenesis and immunomodulation. Bone & Joint Research, 11(4), 189-199. https://doi.org/10.1302/2046-3758.114.BJR-2021-0364.R1
Effects of Distraction Histogenesis
The Distraction Histogenesis5 also triggers Systemic Responses such as recruitment of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs). These activities play important roles in regulating the bone regeneration and the remodelling of new vessels during the Distraction Histogenesis.
With a better understanding of the biological mechanisms, the application of the Distraction Histogenesis technique has been extended to the treatment of skin wounds, joint diseases and vascular diseases.
Below you will find a schematic illustration of Local and Systemic Responses during Distraction Histogenesis.
5-Kong, L.-C. et al. (2020). An update to the advances in understanding distraction histogenesis: From biological mechanisms to novel clinical applications.
Journal of Orthopaedic Translation, 25, 3-10. https://doi.org/10.1016/j.jot.2020.09.003
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